| Boehringer Ingelheim Cares Foundation Inc | Ridgefield | 11 | $11.2B | $1.0B |
| The Andrew W Mellon Foundation | New York | 6719 | $4.8B | $716K |
| Carnegie Corporation of New York | New York | 8597 | $2.2B | $260K |
| The Schmidt Family Foundation | Palo Alto | 5207 | $1.2B | $236K |
| John S and James L Knight Foundation | Miami | 4052 | $1.1B | $264K |
| Ewing Marion Kauffman Foundation | Kansas City | 4357 | $888.9M | $204K |
| Alfred P Sloan Foundation | New York | 4143 | $751.1M | $181K |
| The Annenberg Foundation | Conshohocken | 4790 | $706.1M | $147K |
| Charles Koch Foundation | Arlington | 1991 | $698.0M | $351K |
| Mastercard Impact Fund | Purchase | 666 | $672.3M | $1.0M |
| Blue Dot Foundation | Washington | 147 | $610.8M | $4.2M |
| The Bush Foundation | St Paul | 1583 | $559.4M | $353K |
| Breakthrough Prize Foundation | Washington | 953 | $346.0M | $363K |
| Charles and Helen Schwab Foundation | San Francisco | 887 | $339.0M | $382K |
| Arcus Foundation | New York | 3572 | $298.2M | $83K |
| Salesforcecom Foundation | San Francisco | 201 | $281.3M | $1.4M |
| The Terry Foundation | Houston | 178 | $261.1M | $1.5M |
| Xq Institute | Oakland | 264 | $229.2M | $868K |
| The Spencer Foundation | Chicago | 2352 | $227.1M | $97K |
| The Hawks Foundation | Omaha | 1503 | $217.2M | $145K |
| Northwestern Mutual Life Foundation Inc | Milwaukee | 9 | $216.0M | $24.0M |
| Cigna Foundation | Philadelphia | 31315 | $189.4M | $6K |
| The Duffield Family Foundation | Pleasanton | 4922 | $180.9M | $37K |
| Hca Healthcare Foundation | Nashville | 6273 | $180.3M | $29K |
| Accenture Foundation Inc | Chicago | 238 | $178.0M | $748K |
| The Skillman Foundation | Detroit | 2556 | $161.0M | $63K |
| Edward P Evans Foundation | Andover | 401 | $160.3M | $400K |
| Ray & Kay Eckstein Charitable Trust | Paducah | 1754 | $157.5M | $90K |
| The Resslergertz Foundation | Encino | 518 | $140.7M | $272K |
| Baptist Community Ministries | New Orleans | 3629 | $133.1M | $37K |
| Western Opportunity Fund | Denver | 11 | $128.6M | $11.7M |
| Gilead Foundation | Foster City | 380 | $124.8M | $328K |
| At&T Foundation | Dallas | 4145 | $112.3M | $27K |
| The Heckscher Foundation for Children | New York | 924 | $109.0M | $118K |
| Math for America | New York | 6907 | $106.5M | $15K |
| The Morehead-Cain Foundation | Chapel Hill | 3403 | $103.8M | $31K |
| S&P Global Foundation | New York | 168 | $103.0M | $613K |
| The Mcconnell Foundation | Redding | 1189 | $101.1M | $85K |
| Dell Loy Hansen Foundation | Logan | 122 | $99.6M | $816K |
| Abraham J and Phyllis Katz Foundation | Newnan | 502 | $97.8M | $195K |
| Doris and Bill Scharpf Foundation | Albany | 236 | $95.4M | $404K |
| Vinik Family Foundation | Tampa | 1291 | $92.5M | $72K |
| Hagan Scholarship Foundation | Columbia | 25 | $92.5M | $3.7M |
| Beemok Family Foundation | Charleston | 218 | $92.2M | $423K |
| James Annenberg La Vea Charitable Foundation | Philadelphia | 185 | $90.1M | $487K |
| Kimberly-Clark Foundation | Irving | 85 | $89.7M | $1.1M |
| Abell-Hanger Foundation | Midland | 3075 | $88.8M | $29K |
| Morgan Stanley Foundation Inc | New York | 4253 | $88.4M | $21K |
| Sc Johnson Giving Inc | Racine | 554 | $87.6M | $158K |
| Alfred E Mann Family Foundation | Los Angeles | 700 | $87.5M | $125K |
| Target Als Foundation Inc | New York | 400 | $86.7M | $217K |
| Greater Texas Foundation | Bryan | 865 | $83.7M | $97K |
| Drs Kiran & Pallavi Patel 2017 Foundation | Tampa | 74 | $81.5M | $1.1M |
| Bentson Foundation | Wayzata | 706 | $79.9M | $113K |
| Club for the Future | Kent | 82 | $76.0M | $927K |
| Enoch Trust | New York | 42 | $75.9M | $1.8M |
| Thompson Foundation | Plymouth | 110 | $73.8M | $671K |
| Capital One Foundation Inc | Mclean | 398 | $72.5M | $182K |
| Ameren Charitable Trust (Union Electric | Chicago | 12 | $68.8M | $5.7M |
| Siemens Foundation | Iselin | 209 | $67.5M | $323K |
| Waitt Foundation | North Sioux City | 338 | $66.5M | $197K |
| Davidow Family Foundation | Woodside | 411 | $66.3M | $161K |
| Bill and Carol Latimer Charitable | Union City | 364 | $66.0M | $181K |
| Lola G Duff & William H Duff II Scholarship | Pittsburgh | 12 | $63.2M | $5.3M |
| Perkins Malo Hunter Foundation | Holland | 575 | $63.2M | $110K |
| Mcelhattan Foundation | Pittsburgh | 823 | $62.4M | $76K |
| Hough Family Foundation Inc | St Petersburg | 341 | $59.7M | $175K |
| Tr Col Theo Semcampbellequity-Misc | Orlando | 14 | $59.6M | $4.3M |
| Ruth Mott Foundation | Flint | 742 | $58.3M | $79K |
| Herbst Foundation Inc | San Francisco | 16 | $57.8M | $3.6M |
| Medina Foundation | Seattle | 3071 | $57.6M | $19K |
| The Julia Burke Foundation | San Francisco | 215 | $56.8M | $264K |
| Jf Maddox Foundation | Hobbs | 1516 | $55.8M | $37K |
| Suffolk Cares Charitable Foundation | Boston | 1459 | $53.1M | $36K |
| The Draper Foundation | San Mateo | 733 | $52.8M | $72K |
| Flinn Foundation | Phoenix | 700 | $51.0M | $73K |
| Manzana Foundation | Yakima | 358 | $49.6M | $138K |
| The Joe W and Dorothy D Brown | Metairie | 12 | $48.4M | $4.0M |
| The Teagle Foundation | New York | 1331 | $48.0M | $36K |
| The Stephen Phillips Memorial | Boston | 6003 | $47.7M | $8K |
| American Educational Assistance | Nashville | 10 | $46.2M | $4.6M |
| College Spark Washington | Seattle | 598 | $46.0M | $77K |
| Firebird Foundation for | Phillips | 299 | $45.4M | $152K |
| Watson-Brown Foundation Inc | Thomson | 1517 | $44.7M | $29K |
| Western Union Foundation | Denver | 2841 | $43.3M | $15K |
| Pickett & Hatcher Educational Fund Inc | Columbus | 10 | $43.1M | $4.3M |
| The Debakey Medical Foundation | Houston | 88 | $42.8M | $487K |
| Tortora Sillcox Family Foundation | New York | 23 | $42.0M | $1.8M |
| The Solich Fund | Denver | 266 | $41.8M | $157K |
| Independence Foundation | Philadelphia | 3036 | $41.8M | $14K |
| Bettye Poetz Ferguson Foundation | San Francisco | 26 | $41.0M | $1.6M |
| Paul E Andrews Jr Foundation | Fort Worth | 497 | $39.6M | $80K |
| The Tikvah Fund | New York | 59 | $39.2M | $664K |
| Heisman Trophy Trust | New York | 597 | $38.4M | $64K |
| Charles B Keesee Educational Fund | Martinsville | 211 | $38.2M | $181K |
| Bailey Family Foundation Inc | Tampa | 36 | $37.8M | $1.0M |
| The Rogers Foundation | Las Vegas | 371 | $37.7M | $102K |
| Ab Nicholas Scholarship Foundation | Mequon | 4748 | $37.4M | $8K |
| Canfield Family Foundation | Austin | 24 | $37.1M | $1.5M |
| Rooted Alliance Inc | Chicago | 107 | $36.8M | $344K |
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